HOW CHEMICAL INJURY/CHEMICAL SENSITIVITY AFFECTS THE BODY (pg 2)
DAMAGE TO CELL COMMUNICATION
Free radicals are tissue damaging.2 This damage can include damage to pumping mechanisms on membranes of cells and structures within cells.6 When these pumps are damaged, they cannot function normally to provide the proper concentration of nutrients within the cell and cell structure for normal function. This can lead to marked changes in cell function.
Chemicals can impair the ability of membrane receptor sites to regulate activities within a body cell and interfere with cell messenger systems that communicate between cells.
Damaged cell communication interferes with hormones, digestion, circulation, nerve/brain function and many other body functions.
DAMAGE LEADING TO CELL DEATH
Toxic damage to energy structures can lead to cell death,2 since energy is essential to cell survival. Toxic injury with energy structure damage leads to increased concentration of acid in the body with excess body acid levels.2 In this state of excess body acid, cell function does not occur normally. Increased body acid excess body acid is typical of patients with chronic symptoms from chemical and toxic injury.8
DAMAGE TO CELL STRUCTURES AND TO CELL REPAIR ABILITY
All cells and all structures within cells have lipid (essential fat) membranes around them to hold them together. Free radicals can damage lipid membranes of cells.2 This creates lipid peroxides2 and impaired cell membrane structure and function. This can damage the ability of cells to receive nutrients and impair cell excretion of waste products.
Free radicals also damage proteins,2 including protein needed to repair cell damage and build new cells. Membrane pumps needed for proper regulation of body function are made of protein. Both repair and function are slowed down.
Less available proteins can also harm enzymes. Enzymes are needed for hundreds of body functions. Some proteins carry nutrients (such as ferritin to carry iron, proteins to carry copper to body cells, etc.).2
Some brain cell messages need special proteins to function normally: these are often damaged in chemical injury.
HORMONE FUNCTION DAMAGE
Hormones need proteins to be carried through the blood stream. Damaged proteins can damage hormone function.
Protein deficiency can make some hormones have excess activity and can interfere with function of other hormones.
DAMAGE TO ALL BODY ORGANS
Free radical damage can alter cells in a manner that leads to autoimmune disease. Free radical damage to DNA (genetic material) can lead to cancer.2,9
Free radical damage can affect many organs,2 leading cell damage and to impaired function of the liver, kidneys, lungs/respiratory tract, brain/nervous system, endocrine and immune systems, accelerated degenerative diseases,2 increased osteoporosis of bones, and speed up the aging process.
As discussed above, there are many types of damaging free radicals, all causing body damage. There are multiple ways these free radicals are produced. These include neural sensitization, the inflammation it produces, and abnormal detoxification. Each of these produces multiple types of damaging free radicals. These damaging substances circulate through the body and can damage all body organs.
INCREASED NUTRITIONAL AND SUPPLEMENT NEEDS TO HELP REPAIR
Detoxification requires nutrient cofactors and substances which can be depleted. These include glutathione, bioflavinoids, branched chain protein amino acids, phospholipids, vitamin B12 (cobalamine), folic acid, pyridoxine, (vitamin B6) riboflavin (vitamin B2) and niacin (vitamin B3).2
Detoxification enzymes use oxygen and the bioactive form of niacin known as NADH (nicotinamide adenine dinucleotide).2 Since NADH is used as an energy source for many hundreds of body biochemical functions, increased need for detoxification depletes the NADH reserve for other body functions.
Detoxification uses essential body nutrients to make the chemicals more water soluble so they can be excreted in the bile and urine.2 These nutrients are then depleted from the body, since they are excreted.2 These detoxification nutrients include glutathione, taurine, sulfate, glycine, glutamine, N-acetylcysteine, methionine, and glucuronide.2
Taurine is needed for production of bile acids for digestion, so its depletion from detoxification impairs bile acid production. Bile acids are needed to digest dietary fat. Thus impaired bile acid reduces absorption of essential lipids such as omega-3’s, which are essential to repair chemical damage to cell membrane structures and brain myelin.
Many toxic chemicals are excreted through the bile into the intestinal tract and/or through the kidneys into the urine. Keeping the body and thus urine slightly alkaline helps toxic excretion.10 Urine pH about 7 and not more acid than 6 is ideal. Other detoxification steps work better within slightly alkaline body cells. Detoxification steps tend to create more acid. Inflammation also increases body acid. Thus diets that reduce this acid help maintain better body function. Nutritionists call this an “alkaline diet”.
Bibliography: How Chemical Injury/Chemical Senstivity Affect the Body
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